Reassign the "ctrl+s" hot key to "Save & Reload".(Goto Builder Menu "Tools" > "IDE Settings" > "IDE Hot Keys" , locate "Save & Reload" , double click and press CTRL S keys)
Quickly locate a component using "ctrl+click" on a GUI control in the canvas to select the component on the "Component Hiearchy" palette. (NOTE : the matrix component swallows the "ctrl+click". So in order to click select a matrix control, you must do the clik on the little grey patch under the vertical scrollbar where the events bubbling is not cancel)
Float the "Component Libraries" palette to give more display area for the "Properties Editor" and "Event Editor" palettes. (This is really just a preference, but I find it useful since you can see more of the properties at a glance).
Update
Context sensitive help press keys "alt+F1" while focusing on the component you like get help on (For example, component hiearchy tree) to open the HTML Doc page on the component.